zur Nieden Research Group at UC Riverside

Perturbations in Osteogenic Cell Fate Following Exposure to Constituents Present in Tobacco: A Combinatorial Study. 

Madrid, J. V., Vera-Colón, M. K. M., & Zur Nieden, N. I. (2023). Toxics, 11(12), 998. https://doi.org/10.3390/toxics11120998

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Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation.

Yang, Y. Y., Soh, R., Vera-Colón, M., Huang, M., Zur Nieden, N. I., & Wang, Y. 2023;

Analytical chemistry, 95(17), 6879–6887. https://doi.org/10.1021/acs.analchem.2c05781

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Temporal Profiling of Epitranscriptomic Modulators during Osteogenic Differentiation of Human Embryonic Stem Cells.

Yin, J., Qi, T. F., Yang, Y. Y., Vera-Colón, M., Zur Nieden, N. I., & Wang, Y. 2023; 

Journal of proteome research, 22(7), 2179–2185. https://doi.org/10.1021/acs.jproteome.3c00215

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Sidestream Smoke Extracts from Harm-Reduction and Conventional Camel Cigarettes Inhibit Osteogenic Differentiation via Oxidative Stress and Differential Activation of intrinsic Apoptotic Pathways.

Sparks, N. R. L., Walker, L. M., Sera, S. R., Madrid, J. V., Hanna, M., Dominguez, E. C., & Zur Nieden, N. I. 2022; 

Antioxidants (Basel, Switzerland), 11(12), 2474. https://doi.org/10.3390/antiox11122474

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Embryonic Exposure to Cigarette Smoke Extract Impedes Skeletal Development and Evokes Craniofacial Defects in Zebrafish. 

Karmach, O., Madrid, J. V., Dasgupta, S., Volz, D. C., & Zur Nieden, N. I. 2022;

International journal of molecular sciences, 23(17), 9904. https://doi.org/10.3390/ijms23179904

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Exposure to cigarette smoke impedes human osteoblast differentiation independently of nicotine.

Martinez, I., Sparks, N., Madrid, J. V., Talbot, P., & Zur Nieden, N. I.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2022; ntac144. Advance online publication. https://doi.org/10.1093/ntr/ntac144

 

An Evaluation of Human Induced Pluripotent Stem Cells to Test for Cardiac Developmental Toxicity.

Walker, L. M., Sparks, N., Puig-Sanvicens, V., Rodrigues, B., & Zur Nieden, N. I.

International journal of molecular sciences. 2021;22(15), 8114. https://doi.org/10.3390/ijms22158114

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The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness.

Soh, R., Hardy, A., & Zur Nieden, N. I.

Free radical biology & medicine. 2021.04.022; 169, 224–237. https://doi.org/10.1016/j.freeradbiomed.

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Video-based calcification assay: A novel method for kinetic analysis of osteogenesis in live cultures

Martinez, I. K., Bhanu, B., & Zur Nieden, N. I.

MethodsX. 2021; 8, 101265. https://doi.org/10.1016/j.mex.2021.101265

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Maternal-to-zygotic transition as a potential target for niclosamide during early embryogenesis. T

Vliet, S., Dasgupta, S., Sparks, N., Kirkwood, J. S., Vollaro, A., Hur, M., Zur Nieden, N. I., & Volz, D. C. 

Toxicology and applied pharmacology. 2019;380, 114699. https://doi.org/10.1016/j.taap.2019.114699

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Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage.

Madrid JV, Sera SR, Sparks NRL, Zur Nieden NI.

Methods Mol Biol. 2018;1797:125-145. doi: 10.1007/978-1-4939-7883-0_5.

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Low Osteogenic Yield in Human Pluripotent Stem Cells Associates with Differential Neural Crest Promoter Methylation.

Sparks NRL, Martinez IKC, Soto CH, Zur Nieden NI.

Stem Cells. 2018 Mar;36(3):349-362. doi: 10.1002/stem.2746.

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Video-based kinetic analysis of calcification in live osteogenic human embryonic stem cell cultures reveals the developmentally toxic effect of Snus tobacco extract.

Martinez IKC, Sparks NRL, Madrid JV, Affeldt H 3rd, Vera MKM, Bhanu B, Zur Nieden NI.

Toxicol Appl Pharmacol. 2019 Jan 15;363:111-121. doi: 10.1016/j.taap.2018.11.006. Epub 2018 Nov 20.

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microRNA Regulation of Skeletal Development.

Sera SR, Zur Nieden NI.

Curr Osteoporos Rep. 2017 Aug;15(4):353-366. doi: 10.1007/s11914-017-0379-7. Review.

 

Impact of fluidic agitation on human pluripotent stem cells in stirred suspension culture.

Nampe D, Joshi R, Keller K, Zur Nieden NI, Tsutsui H.

Biotechnol Bioeng. 2017 Sep;114(9):2109-2120. doi: 10.1002/bit.26334. Epub 2017 May 23.

 

Glucose-Induced Oxidative Stress Reduces Proliferation in Embryonic Stem Cells via FOXO3A/β-Catenin-Dependent Transcription of p21(cip1).

McClelland Descalzo DL, Satoorian TS, Walker LM, Sparks NR, Pulyanina PY, Zur Nieden NI.

Stem Cell Reports. 2016 Jul 12;7(1):55-68. doi: 10.1016/j.stemcr.2016.06.006.

 

Wnt5a Supports Osteogenic Lineage Decisions in Embryonic Stem Cells.

Keller KC, Ding H, Tieu R, Sparks NR, Ehnes DD, Zur Nieden NI.

Stem Cells Dev. 2016 Jul 1;25(13):1020-32. doi: 10.1089/scd.2015.0367. Epub 2016 Jun 1.

 

Cardiac differentiation potential of human induced pluripotent stem cells in a 3D self-assembling peptide scaffold.

Puig-Sanvicens VA, Semino CE, Zur Nieden NI.

Differentiation. 2015 Nov-Dec;90(4-5):101-10. doi: 10.1016/j.diff.2015.11.002. Epub 2015 Dec 18.

 

Embryonic stem cell-derived osteocytes are capable of responding to mechanical oscillatory hydrostatic pressure.

Ehnes DD, Price FD, Shrive NG, Hart DA, Rancourt DE, zur Nieden NI.

J Biomech. 2015 Jul 16;48(10):1915-21. doi: 10.1016/j.jbiomech.2015.04.015. Epub 2015 Apr 16.

 

Exogenous nitric oxide enhances calcification in embryonic stem cell-derived osteogenic cultures.

Ehnes DD, Geransar RM, Rancourt DE, Zur Nieden NI.

Differentiation. 2015 Mar-Apr;89(3-4):97-103. doi: 10.1016/j.diff.2015.02.001. Epub 2015 Apr 27.

 

Fluorescent hydrogels for embryoid body formation and osteogenic differentiation of embryonic stem cells.

zur Nieden NI, Turgman CC, Lang X, Larsen JM, Granelli J, Hwang YJ, Lyubovitsky JG.

ACS Appl Mater Interfaces. 2015 May 20;7(19):10599-605. doi: 10.1021/acsami.5b02368. Epub 2015 May 11.

 

Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model.

Barrientos-Durán A, Carpenter EM, Zur Nieden NI, Malinin TI, Rodríguez-Manzaneque JC, Zanello LP.

Int J Nanomedicine. 2014 Sep 9;9:4277-91. doi: 10.2147/IJN.S62538. eCollection 2014.

 

Stem cells for osteodegenerative diseases: current studies and future outlook.

McClelland Descalzo DL, Ehnes DD, zur Nieden NI.

Regen Med. 2014 Mar;9(2):219-30. doi: 10.2217/rme.13.100. Review.

 

Suspension culture of pluripotent stem cells: effect of shear on stem cell fate.

Keller KC, Rodrigues B, zur Nieden NI.

Crit Rev Eukaryot Gene Expr. 2014;24(1):1-13. Review.

 

Osteogenic induction from marmoset embryonic stem cells cultured in feeder-dependent and feeder-independent conditions.

Trettner S, Findeisen A, Taube S, Horn PA, Sasaki E, zur Nieden NI.

Osteoporos Int. 2014 Apr;25(4):1255-66. doi: 10.1007/s00198-013-2566-4. Epub 2014 Feb 15.

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NO-β-catenin crosstalk modulates primitive streak formation prior to embryonic stem cell osteogenic differentiation.

Ding H, Keller KC, Martinez IK, Geransar RM, zur Nieden KO, Nishikawa SG, Rancourt DE, zur Nieden NI.

J Cell Sci. 2012 Nov 15;125(Pt 22):5564-77. doi: 10.1242/jcs.081703. Epub 2012 Sep 3.

 

Embryonic stem cell test: stem cell use in predicting developmental cardiotoxicity and osteotoxicity.

Kuske B, Pulyanina PY, zur Nieden NI.

Methods Mol Biol. 2012;889:147-79. doi: 10.1007/978-1-61779-867-2_10. Review.

 

Derivation of neural progenitors and retinal pigment epithelium from common marmoset and human pluripotent stem cells.

Torrez LB, Perez Y, Yang J, Zur Nieden NI, Klassen H, Liew CG.

Stem Cells Int. 2012;2012:417865. doi: 10.1155/2012/417865. Epub 2012 Mar 20.

 

Attenuated reovirus displays oncolysis with reduced host toxicity.

Kim M, Garant KA, zur Nieden NI, Alain T, Loken SD, Urbanski SJ, Forsyth PA, Rancourt DE, Lee PW, Johnston RN.

Br J Cancer. 2011 Jan 18;104(2):290-9. doi: 10.1038/sj.bjc.6606053. Epub 2010 Dec 21.

 

Absorption-based assays for the analysis of osteogenic and chondrogenic yield.

Davis LA, Dienelt A, zur Nieden NI.

Methods Mol Biol. 2011;690:255-72. doi: 10.1007/978-1-60761-962-8_17.

 

Improved media compositions for the differentiation of embryonic stem cells into osteoblasts and chondrocytes.

Kuske B, Savkovic V, zur Nieden NI.

Methods Mol Biol. 2011;690:195-215. doi: 10.1007/978-1-60761-962-8_14.

 

Embryoid body formation: recent advances in automated bioreactor technology.

Trettner S, Seeliger A, zur Nieden NI.

Methods Mol Biol. 2011;690:135-49. doi: 10.1007/978-1-60761-962-8_9.

 

Embryonic stem cells for osteo-degenerative diseases.

zur Nieden NI.

Methods Mol Biol. 2011;690:1-30. doi: 10.1007/978-1-60761-962-8_1. Review.

 

Hyperglycemia impairs skeletogenesis from embryonic stem cells by affecting osteoblast and osteoclast differentiation.

Dienelt A, zur Nieden NI.

Stem Cells Dev. 2011 Mar;20(3):465-74. doi: 10.1089/scd.2010.0205. Epub 2010 Nov 30.

 

Monolayer cultivation of osteoprogenitors shortens duration of the embryonic stem cell test while reliably predicting developmental osteotoxicity.

zur Nieden NI, Davis LA, Rancourt DE.

Toxicology. 2010 Nov 9;277(1-3):66-73. doi: 10.1016/j.tox.2010.08.016. Epub 2010 Sep 15.

 

Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test.

zur Nieden NI, Davis LA, Rancourt DE.

Toxicol Appl Pharmacol. 2010 Sep 1;247(2):91-7. doi: 10.1016/j.taap.2010.05.010. Epub 2010 May 26.

 

Assessing developmental osteotoxicity of chlorides in the embryonic stem cell test.

zur Nieden NI, Baumgartner L.

Reprod Toxicol. 2010 Sep;30(2):277-83. doi: 10.1016/j.reprotox.2010.04.014. Epub 2010 May 4.

 

Reduced differentiation efficiency of murine embryonic stem cells in stirred suspension bioreactors.

Taiani JT, Krawetz RJ, Zur Nieden NI, Elizabeth Wu Y, Kallos MS, Matyas JR, Rancourt DE.

Stem Cells Dev. 2010 Jul;19(7):989-98. doi: 10.1089/scd.2009.0297.

 

Morphogenetic and regulatory mechanisms during developmental chondrogenesis: new paradigms for cartilage tissue engineering.

Quintana L, zur Nieden NI, Semino CE.

Tissue Eng Part B Rev. 2009 Mar;15(1):29-41. doi: 10.1089/ten.teb.2008.0329. Review.

 

Mesodermal fate decisions of a stem cell: the Wnt switch.

Davis LA, Zur Nieden NI.

Cell Mol Life Sci. 2008 Sep;65(17):2658-74. doi: 10.1007/s00018-008-8042-1. Review.

 

Properties of murine embryonic stem cells maintained on human foreskin fibroblasts without LIF.

Meng GL, Zur Nieden NI, Liu SY, Cormier JT, Kallos MS, Rancourt DE.

Mol Reprod Dev. 2008 Apr;75(4):614-22.

 

Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors.

Cormier JT, zur Nieden NI, Rancourt DE, Kallos MS.

Tissue Eng. 2006 Nov;12(11):3233-45.

 

Embryonic stem cells remain highly pluripotent following long term expansion as aggregates in suspension bioreactors.

zur Nieden NI, Cormier JT, Rancourt DE, Kallos MS.

J Biotechnol. 2007 May 1;129(3):421-32. Epub 2007 Jan 21.

 

Steering embryonic stem cell fate towards osteoblasts with downstream non-canonical wnt targets in vitro.

Taube S, Zur Nieden N.

J Stem Cells Regen Med. 2007 May 16;2(1):132. eCollection 2007. No abstract available.

 

Gene profiling on mixed embryonic stem cell populations reveals a biphasic role for beta-catenin in osteogenic differentiation.

zur Nieden NI, Price FD, Davis LA, Everitt RE, Rancourt DE.

Mol Endocrinol. 2007 Mar;21(3):674-85. Epub 2006 Dec 14.

 

Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages.

zur Nieden NI, Kempka G, Rancourt DE, Ahr HJ.

BMC Dev Biol. 2005 Jan 26;5:1.

 

Molecular multiple endpoint embryonic stem cell test--a possible approach to test for the teratogenic potential of compounds.

zur Nieden NI, Kempka G, Ahr HJ.

Toxicol Appl Pharmacol. 2004 Feb 1;194(3):257-69.

 

In vitro differentiation of embryonic stem cells into mineralized osteoblasts.

zur Nieden NI, Kempka G, Ahr HJ.

Differentiation. 2003 Jan;71(1):18-27.

 

Molecular markers in embryonic stem cells.

zur Nieden NI, Ruf LJ, Kempka G, Hildebrand H, Ahr HJ.

Toxicol In Vitro. 2001 Aug-Oct;15(4-5):455-61.